Recently an article in?Science Translation Medicine took a close look at factors both environmental and genetic that contribute to degenerative brain disease.
And what researchers have found is that there is a genetic varient that when combined with traumatic brain injury increases the risk of long-term degenerative brain disease.
The genetic varient is APOE-4 status and it is associated with higher risks for Alzheimer?s disease. When exposure to traumatic brain injury is added it is also associated with a higher risks for long-term degenerative brain disease.
Both traumatic brain injury and mild traumatic brain injury are devastating disease brought on by trauma or sudden acceleration or deceleration of the brain.
Over 1.5 million individuals are effected by these diseases or injuries every year. But what this new research regarding APOE-4 may shed light on is why some individuals recover with no long-term problems and others simply do not.
For instance, in the area of MTBI or mild traumatic brain injuries, everyone working in the field knows that about 85% of those patients will recover from a MTBI with little to know long-term consequences. But the other 15% will not. And many of those individuals will suffer debilitating and disabling symptoms.
So, in the near future genetic testing may be able to determine a persons risk regarding the development of long-term degenerative brain disease due to exposure to traumatic brain injury. And this, in turn, could allow individuals ? like athletes or potential soldiers ? to make informed decisions about activities and careers.
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