Monday, November 28, 2011

Maggie Gyllenhaal & Peter Sarsgaard Expecting Second Child

The actors are expecting their second child together, her rep confirms to PEOPLE.

Source: http://feeds.celebritybabies.com/~r/celebrity-babies/~3/E4mPfGh7D-Y/

oakland raiders carson palmer al davis edmund fitzgerald vincent brown vincent brown willow smith

Stockard Channing shrugs off pain to hit the stage

FILE - In this June 7, 2009, file photo, actress Stockard Channing arrives at the 63rd Annual Tony Awards in New York. Channing, the Tony Award-winning star of Broadway?s play ?Other Desert Cities,? has had to leave the production after undergoing knee surgery. The play also features Stacy Keach, Judith Light and Rachel Griffiths in her Broadway debut. (AP Photo/Peter Kramer, file)

FILE - In this June 7, 2009, file photo, actress Stockard Channing arrives at the 63rd Annual Tony Awards in New York. Channing, the Tony Award-winning star of Broadway?s play ?Other Desert Cities,? has had to leave the production after undergoing knee surgery. The play also features Stacy Keach, Judith Light and Rachel Griffiths in her Broadway debut. (AP Photo/Peter Kramer, file)

(AP) ? Stockard Channing has made a speedy ? some might say miraculous ? return to Broadway.

The 67-year-old Tony Award-winner performed in "Other Desert Cities" on Friday night and plans to continue in the show despite undergoing arthroscopic surgery on her right knee less than a week ago.

Channing felt her knee collapse backstage after the Nov. 18 show and missed seven performances. She plans to perform in Saturday night's show and Sunday's matinee. An understudy performed Saturday's matinee and will do Wednesday's matinee.

The Jon Robin Baitz play, about a dysfunctional family wrestling with a deep secret, opened Nov. 3.

In an interview Friday before her return, Channing said: "This is maybe stupid. I don't know. But if it doesn't blow up or get painful, I'm doing the right thing."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2011-11-26-Theater-Stockard%20Channing/id-3b9a97db64c64c7b86353d9c9efb88ab

cyber monday deals 2011 cyber monday deals 2011 cybermonday deals cybermonday deals kourtney and kim take new york occupy la syracuse basketball

Email From a Cop (Theagitator)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories Stories, News Feeds and News via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/166659447?client_source=feed&format=rss

pete seeger gazelle gazelle pumpkin carving patterns pumpkin carving patterns lizzie borden lizzie borden

Sunday, November 27, 2011

Latino Republicans Face Scrutiny Of Own Immigrant Past Due To GOP's Conservative Views On Immigration

ALBUQUERQUE, N.M. -- New Mexico Gov. Susana Martinez is forced to research and clarify her late grandfather's immigration status. Marco Rubio, Florida's GOP Senator, is accused of embellishing his family's immigrant story. A Republican congressional candidate in California puts on his website that he is the great-grandson of an illegal immigrant.

As more Latino Republicans seek and win elected office, their families' backgrounds are becoming subject to increased scrutiny from some Latino activists, a reaction experts say is a result of Latino Republicans' conservative views on immigration. It's a new phenomenon that experts say Latino Democrats rarely faced, and could be recurring feature in elections as the Republican Party seeks to recruit more Latino candidates.

"It's a trend and we are seeing more of it," said Alfonso Aguilar, executive director of the Washington, D.C.-based Latino Partnership for Conservative Principles.

For years, most Latino elected officials were largely Democrats, except in Florida where Cuban Americans tended to vote Republican. But recently, a new generation of Latino Republicans has won seats in Arizona, Texas, New Mexico, California and even Idaho. Those politicians have come under fire from some Latino activists for pushing for laws targeting illegal immigrants and for opposing efforts for comprehensive immigration reform ? views that are in line with most Republicans.

And the immigrant advocates are pointing to the GOP Latino elected leaders' own family histories in an effort to paint them as hypocrites. Ignacio Garcia, a history professor at Brigham Young University, said it comes from a long tradition by liberal activists of portraying Latino Republicans as "vendidos," or sellouts, since the majority of Latino voters tend to vote Democratic.

For example, Martinez tried twice in the New Mexico state legislature to overturn a state law that allows illegal immigrants to obtain state driver's licenses. Then earlier this year, various media outlets reported that a grandfather of Martinez may have been an illegal immigrant. The reports sparked immigrant advocates to protests outside the state Capitol with poster-size photos of Martinez on drivers' licenses.

Martinez, a Republican and the nation's only Latina governor, ordered her political organization to research her family's background and found documents that suggested that her grandfather legally entered the country and had various work permits.

The episode drew criticism, even from those who opposed Martinez' efforts on state driver's licenses. "This has nothing to do with her views and how she governs," said Michael A. Olivas, an immigration law professor at the University of Houston who also is aiding in a lawsuit against a Martinez's administration probe over the driver's license fight. "I don't think it's fair for people to dig around in her family's past."

In Florida, Rubio's official Senate website until recently described his parents as having fled Cuba following Fidel Castro's takeover. But media organizations reported last month that Rubio's parents and his maternal grandfather emigrated for economic reasons more than two years before the Cuban Revolution.

Somos Republicans, a group dedicated to increasing Latino Republican voting numbers, immediately attacked Rubio over the discrepancy and for holding harsh views on immigration. "We believe it is time to find out the complete history of his parents' immigration history," the group said in a statement. "It is also time for Rubio to be a leader and help Senator Bob Menendez (D-NJ) fix the broken immigration system."

Patricia Montes, executive director of Centro Presente, an immigrant advocacy group in Somerville, Mass., said voters need to know a politician's family background for clues on how they will respond to people with similar stories. "It's very important to voters," said Montes.

Montes said most Latino and immigrant voters don't simply Latino Republicans as "vendidos" but rather as politican leaders who don't share their views. "I don't care if someone is Latina or not," said Montes. "I care if they believe in the same things I do, and if their policies will affect the immigrant community."

Garcia said the current tension also is a result of a new breed of Latino Republicans finally winning high profile seats after years of being largely ignored or dismissed. Garcia said there have always been Hispanic Republicans, through their numbers have been typically small and they have often faced heat from the largely Democratic Latino population.

In New Mexico, for example, the colorful lawman and lawyer Elfego Baca helped established the Republican Party just after New Mexico became a state in 1912 and actively tried recruit the state's mutigenerational Latino population to join the party. Baca won a number of local offices, including district attorney, but lost bids for Congress and various statewide offices.

In Texas, civil rights activist Felix Tijerina, a Mexican-American Houston restaurateur and former national president of the League of United Latin American Citizens in the 1950s, remained committed to Republican Party despite a backlash from fellow activists who disagreed with his laissez faire, pro-business views. One Texas civil right leader, John J. Herrera, called Tijerina "a white man's Mexican" for his support of Republican Dwight D. Eisenhower for president over Democrat Adlai Stevenson.

"The difference now is that these new Latino Republicans like Martinez and Rubio are better prepared and are being groomed as national figures," said Garcia. "Meanwhile, the Democrats are falling behind. They have no equivalent and they aren't giving Latinos the same opportunity."

Garcia said there's also a new factor ? the millions of new independent Latino evangelicals who could be potential GOP voters. This population is new and unpredictable, he said.

Still, some Latino Republicans want to use the new attention around them in the party to change what they see is damaging rhetoric around immigration. Tony Carlos, who is seeking the GOP nomination for California's 3rd Congressional District, is running on a platform to push comprehensive immigration reform and believes if other Republicans follow, more Latinos will vote with the GOP.

On his campaign website Carlos says his great-grandfather came to Arizona from Mexico "without papers." Carlos said it's all about showing that his family is part of an ongoing American story and that political leaders need to honestly attack today's problems

"I'm putting my family history out there. And once Latino voters hear that I support immigration reform, I find that they are open to other issues that appeal to conservatives," said Carlos. "My argument is that they are just as conservative. They are just in the wrong party."

'; var coords = [-5, -72]; // display fb-bubble FloatingPrompt.embed(this, html, undefined, 'top', {fp_intersects:1, timeout_remove:2000,ignore_arrow: true, width:236, add_xy:coords, class_name: 'clear-overlay'}); });

Source: http://www.huffingtonpost.com/2011/11/27/latino-republicans-scrutiny-immigrant-past_n_1115304.html

pumpkin carving texas tech football michigan state michigan state bridge school miami dolphins charlie and the chocolate factory

Amazingly, Pamela Geller's Butterball Fail Continues (Little green footballs)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, RSS Feeds and Widgets via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/166743866?client_source=feed&format=rss

chris hansen sandusky interview with bob costas sandusky interview with bob costas live oak mark kelly mark kelly john hughes

Dubai's City Hospital unveils new cancer treatment | Healthcare ...

StaffStaff
Saturday, November 26 - 2011 at 13:01 UAE local time (GMT+4)

Replication or redistribution in whole or in part is expressly prohibited without the prior written consent of AME Info FZ LLC / Emap Limited.

The information comprised in this section is not, nor is it held out to be, a solicitation of any person to take any form of investment decision. The content of the AMEinfo.com Web site does not constitute advice or a recommendation by AME Info FZ LLC / Emap Limited and should not be relied upon in making (or refraining from making) any decision relating to investments or any other matter. You should consult your own independent financial adviser and obtain professional advice before exercising any investment decisions or choices based on information featured in this AMEinfo.com Web site.

AME Info FZ LLC / Emap Limited can not be held liable or responsible in any way for any opinions, suggestions, recommendations or comments made by any of the contributors to the various columns on the AMEinfo.com Web site nor do opinions of contributors necessarily reflect those of AME Info FZ LLC / Emap Limited.

In no event shall AME Info FZ LLC / Emap Limited be liable for any damages whatsoever, including, without limitation, direct, special, indirect, consequential, or incidental damages, or damages for lost profits, loss of revenue, or loss of use, arising out of or related to the AMEinfo.com Web site or the information contained in it, whether such damages arise in contract, negligence, tort, under statute, in equity, at law or otherwise.

Source: http://www.ameinfo.com/282296.html

megatron richard simmons war of 1812 war of 1812 jeffrey eugenides jeffrey eugenides volcker rule

Saturday, November 26, 2011

DNA Experts and Forensic Genealogists Team Up to Solve Alaskan Mystery (preview)

Feature Articles | Technology Cover Image: December 2011 Scientific American MagazineSee Inside

New fingerprint- and DNA-identification techniques solve a mystery from a 60-year-old plane crash


TRAGEDY: It took nine years to identify the arm recovered from the wreckage of Northwest Flight 4422. No one knows what caused the crash. The plane was off course before it slammed into the mountain. Image: Lines History Department (airplane); Courtesy of Kevin A. McGregor, ? 1999 (man with camera); Courtesy of Roy Wittock (arm); Alaska State Troopers/AP Photo (van Zandt); Courtesy of Mike Grimm, Jr. (fingerprint)

In Brief

  • More than 50 years after the 1948 crash of a Northwest Airlines plane killed all onboard, a desiccated arm and hand were retrieved from the scene.
  • Initial fingerprint examination and DNA analysis of the arm and hand were unable to determine the identity of the remains.
  • Researchers finally identified the remains after developing new techniques that may one day be used for disaster victims and unknown soldiers.

On March 12, 1948, at 9:14 p.m. Pacific Standard Time, Northwest Airlines Flight 4422 crashed into Mount Sanford, a peak in the remote Wrangell Mountains in eastern Alaska. All 24 passengers?merchant mariners returning to the U.S. from Shanghai, China?along with six Northwest crew members, probably died on impact. The debris, too difficult to reach, was quickly covered by snow and eventually entombed by ice.


Articles You Might Also Like

Source: http://rss.sciam.com/click.phdo?i=5d234b0418036e6721d27ec494ed7bd0

post office hours post office hours coptic coptic breaking bad season finale breaking bad season finale jets patriots

Video: What Shoppers Are Watching

Sorry, Readability was unable to parse this page for content.

Source: http://video.msnbc.msn.com/cnbc/45434656/

collegeboard kelsey grammer coco rocha coco rocha al sharpton izon heart attack grill

Bryan Fischer Sounds the Alarm on Butterball Terror Turkeys (Little green footballs)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, News Feeds and News via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/166103944?client_source=feed&format=rss

chanukah 11 11 11 meaning miracle berry billy crystal veterans day thank you veterans day thank you nigel tufnel day

Probe of missing Missouri baby Lisa Irwin scaled back (Reuters)

KANSAS CITY, Missouri (Reuters) ? Police and the FBI have disbanded a command post set up to investigate the disappearance of Missouri infant Lisa Irwin but are still following leads in the case, an official said on Wednesday.

Irwin vanished from her northern Kansas City home October 4, setting off an intense investigation and national media coverage. Investigators pursuing leads in the case are no longer working jointly out of a single office, Captain Steve Young of the Kansas City Police Department said.

There are other crimes that detectives have to investigate, he said.

"This puts things back to normal a little bit more, but we are not washing our hands of this case," Young said.

Irwin's mother, Deborah Bradley, said she last saw her baby when she put Lisa to bed the evening of October 3. Lisa's father, Jeremy Irwin, reported her missing when he returned home from work the next morning. Lisa was 10 months old at the time.

The parents were questioned extensively in the case, but police say they are not suspects.

(Reporting by Kevin Murphy; Editing by Colleen Jenkins and Greg McCune)

Source: http://us.rd.yahoo.com/dailynews/rss/crime/*http%3A//news.yahoo.com/s/nm/20111123/us_nm/us_crime_baby_missing

st.louis cardinals st.louis cardinals drag me to hell alot alot are you afraid of the dark are you afraid of the dark

Friday, November 25, 2011

Penguin reverses course for now on Kindle lending (AP)

SAN FRANCISCO ? One of the country's largest publishers, Penguin Group (USA), is temporarily restoring libraries' ability to loan their e-books for Amazon.com's Kindle ? but only through the end of the year.

The publisher backtracked Wednesday after saying it was informed by Amazon.com Inc. that the online retailer wasn't aware of Penguin's agreement with Overdrive, a leading supplier of e-books to libraries.

Penguin, which is based in New York, had suspended making new e-books available to libraries and said it won't allow libraries to loan any e-books for the Kindle due to unspecified security concerns.

Amazon, based in Seattle, allows Kindle users to borrow e-books from local libraries through a partnership with OverDrive. The partnership vastly increases the Kindle's presence in libraries and encourages patrons to visit Amazon's website and buy books.

Penguin asked OverDrive to disable its "Get for Kindle" function on Penguin books on Monday, and OverDrive said it and Penguin were "in the process of looking at new terms" for libraries.

Now, Penguin says the companies are all working together to "address Penguin's concerns" by the end of 2011.

Amazon declined to comment.

Source: http://us.rd.yahoo.com/dailynews/rss/tech/*http%3A//news.yahoo.com/s/ap/20111123/ap_on_hi_te/us_tec_kindle_penguin_books

russell simmons russell simmons joseph kony joseph kony 9 9 9 delmon young sprint

Police honor man who led them to Lee Harvey Oswald (Providence Journal)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, RSS Feeds and Widgets via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/165368406?client_source=feed&format=rss

occupy wall street second time around bill gates steve jobs bill gates steve jobs brett favre associated press 99%

More than 20 bodies dumped in Mexico's Guadalajara (Reuters)

MEXICO CITY (Reuters) ? Suspected drug gang hitmen murdered more than 20 people and dumped their bodies in the center of Mexico's second city of Guadalajara on Thursday.

Local media reported the bodies were found in several vans abandoned around the western city's iconic Millennium Arches monument, together with a message from drug cartels. The state attorney-general's office said there could be up to 23 dead.

Guadalajara is the capital of the state of Jalisco, home to mariachi music and tequila, and was long spared the beheadings and drive-by shootings that have marked Mexico's war against drugs in other regions.

Known as a stronghold of the Sinaloa cartel, headed by Mexico's most-wanted trafficker Joaquin "Shorty" Guzman, Guadalajara saw a spike in killings as other gangs, including the Zetas, started to contest their dominance of the region.

Local media said the message found with the bodies, dumped less than 1 mile from the exhibition hall where the Guadalajara International Book Fair will be held from Saturday, purported to be from the Zetas and was directed at Guzman.

Officials had blamed a surge of killings in the eastern port city of Veracruz in September and October, seen as a warning to the Zetas, on a group with ties to Guzman.

The discovery of the bodies follows the dumping of 16 charred corpses in the Sinaloan capital Culiacan on Wednesday.

Among the Culiacan dead were at least seven people, three of them police officers, who had been kidnapped from a small Sinaloan town on Monday, a local official said on Thursday.

Mexican President Felipe Calderon has deployed the army to crack down on powerful criminal gangs and some 45,000 people have died in the conflict since he took office.

Guadalajara, home to 4.5 million people, hosted athletes from 42 countries last month for the Pan American Games, which were not marred by security incidents. About 600,000 visitors are expected for the city's book fair, organizers said.

The U.S. consulate in Guadalajara warned on February 3 of "a marked escalation of criminal activity". It banned U.S. government officials from traveling after dark between the city and its main airport and urged U.S. visitors to follow suit.

Drugs violence has already engulfed the northern business hub of Monterrey, a city of similar size to Guadalajara, prompting some companies to freeze investment.

(Writing by Patrick Rucker; editing by Anthony Boadle)

Source: http://us.rd.yahoo.com/dailynews/rss/world/*http%3A//news.yahoo.com/s/nm/20111124/wl_nm/us_mexico_deaths

colorado avalanche colorado avalanche bass lake michael jackson kids michael jackson kids father of the bride father of the bride

Thursday, November 24, 2011

Penguin reverses course for now on Kindle lending

SAN FRANCISCO (AP) ? One of the country's largest publishers, Penguin Group (USA), is temporarily restoring libraries' ability to loan their e-books for Amazon.com's Kindle ? but only through the end of the year.

The publisher backtracked Wednesday after saying it was informed by Amazon.com Inc. that the online retailer wasn't aware of Penguin's agreement with Overdrive, a leading supplier of e-books to libraries.

Penguin, which is based in New York, had suspended making new e-books available to libraries and said it won't allow libraries to loan any e-books for the Kindle due to unspecified security concerns.

Amazon, based in Seattle, allows Kindle users to borrow e-books from local libraries through a partnership with OverDrive. The partnership vastly increases the Kindle's presence in libraries and encourages patrons to visit Amazon's website and buy books.

Penguin asked OverDrive to disable its "Get for Kindle" function on Penguin books on Monday, and OverDrive said it and Penguin were "in the process of looking at new terms" for libraries.

Now, Penguin says the companies are all working together to "address Penguin's concerns" by the end of 2011.

Amazon declined to comment.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/495d344a0d10421e9baa8ee77029cfbd/Article_2011-11-23-Kindle-Penguin%20Books/id-610ee2737b1644d385e537c16b773b69

rick perry paterno oakland raiders carson palmer al davis edmund fitzgerald vincent brown

Obama slaps new sanctions on Iran energy sector (Reuters)

WASHINGTON (Reuters) ? President Barack Obama on Monday ordered new U.S. sanctions on Iran's energy and petrochemical sectors that would punish anyone who helped Iran develop and expand its petroleum resources, the White House said.

The latest U.S. move seeks to step up pressure on Tehran after the U.N. nuclear watchdog highlighted fresh concerns about the possible military dimensions of Iran's nuclear program.

The U.S. Treasury Department also planned to designate Iran as an area of "primary money laundering concern" on Monday, a U.S. official said.

(Reporting Matt Spetalnick, Alister Bull and by Jeff Mason)

Source: http://us.rd.yahoo.com/dailynews/rss/science/*http%3A//news.yahoo.com/s/nm/20111121/pl_nm/us_iran_usa_sanctions_obama

soulja boy jason campbell android ice cream sandwich shia labeouf teleprompter ashley greene mukesh ambani

Fujitsu Arrows Kiss F-03D ladyphone tells you sit up straight, eat your greens

Here in the US, a ladyphone is bit of a hard sell as we saw with the HTC Rhyme but in Japan it's a different story. Fujitsu is trying to woo girls with the Arrows Kiss F-03D, which comes with apps designed to get users into shape -- or bully them to tears. Beauty Body Clinic monitors your posture and orders you to stand up straighter, Sukkiri Alarm wakes you when it thinks you're ready and Karada Life is a pedometer app offering "health maintenance" advice -- probably suggesting a salad the next time you're at KFC. If that hasn't put you off, you'll want to know it's running a single-core 1.4GHz Qualcomm MSM8255, a 3.7-inch WVGA (800 x 480) display and an 8.1 megapixel camera 'round back. If you can stand the nannying, you'll also notice it can handle OneSeg broadcasts, mobile wallet payments and the Okudake-Juden wireless charging system. It'll make its way into the purses of unsuspecting NTT DoCoMo victims customers at an as-yet-unspecified price on November 25th.

Continue reading Fujitsu Arrows Kiss F-03D ladyphone tells you sit up straight, eat your greens

Filed under:

Fujitsu Arrows Kiss F-03D ladyphone tells you sit up straight, eat your greens originally appeared on Engadget on Tue, 22 Nov 2011 23:18:00 EDT. Please see our terms for use of feeds.

Permalink Far East Gizmos  |  sourceFujitsu  | Email this | Comments


Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/uirCLbAakWk/

apple press conference apple event apple event buccaneers buccaneers bernanke bernanke

Surprising pathway implicated in stuttering

ScienceDaily (Nov. 22, 2011) ? Researchers at Washington University School of Medicine in St. Louis have obtained new evidence that at least some persistent stuttering is caused by mutations in a gene governing not speech, but a metabolic pathway involved in recycling old cell parts.

Beyond a simple association, the study provides the first evidence that mutations affecting cellular recycling centers called lysosomes actually play a role in causing some people to stutter.

"This was extremely unexpected," says senior author Stuart A. Kornfeld, MD, the David C. and Betty Farrell Professor of Medicine. "Why would impairment in a lysosomal pathway lead to stuttering? We don't know the answer to that. Partly because we don't know very much about the mechanisms of speech, including which neurons in the brain are involved. So we can't fully explain stuttering, but now we have clues."

The research is available online in the Journal of Biological Chemistry

Genetic clues to stuttering were first identified in a paper published in the New England Journal of Medicine in February 2010. In it, Dennis Drayna, PhD, a senior investigator with the National Institute on Deafness and Other Communication Disorders and a co-author on the current study, and his colleagues reported results of genetic studies on members of a large Pakistani family, many of whom stutter.

Among most of the stuttering family members, they found mutations in three genes involved in directing proteins to the lysosome. These same mutations were present in many unrelated individuals in Pakistan, North America and Europe who stutter, but not in those with normal speech.

"They found mutations in three genes that encode a pathway for directing newly made lysosomal enzymes to the lysosomes," Kornfeld says. "And it turned out to be a pathway we discovered years ago. So this is a nice collaboration."

Until now, one of the three genes, NAGPA, had not been implicated in any human disorder. This is where Kornfeld and Wang-Sik Lee, PhD, research instructor in medicine at Washington University, began their in-depth biochemical investigation of the mutations that Drayna's group identified.

NAGPA encodes an enzyme responsible for the last step in "addressing" proteins to the lysosome. Drayna's work identified three separate mutations in NAGPA in individuals who stutter. And according to Lee's biochemical analysis, all three of the mutations impaired the enzyme, but each did so in a different way. In general, mutations in a gene often cause the resulting protein to be folded into the wrong shape. Cells are very good at recognizing misfolded proteins and destroying them.

In this case, Lee's biochemical analysis shows that two mutations appear to trap the proteins in the cell's protein manufacturing center, though some get out before being destroyed.

"It's not an all-or-nothing thing," Kornfeld says. "Of the material that does get out, its activity is normal."

But the third mutation causes a larger folding problem and the protein is destroyed just minutes after being made.

Such findings offer a glimpse at possible future therapies for stuttering. For two of the mutations at least, the problem is not that the protein can't function, but rather that it can't get out of the cell's protein manufacturing center and go to the intracellular site where it acts to direct proteins to lysosomes. If some compound can be found that helps the protein escape, Lee's work suggests that it would function normally. But Kornfeld cautions that this type of therapy for stuttering is a long way off.

"There are billions of neurons in the brain, and we have very little idea which neurons are involved in speech," he says. "Our main finding is that these three mutations in NAGPA in people with persistent stuttering all have harmful effects. This is biochemical evidence that these mutations are meaningful, and not just markers of some other genetic change that is the real cause."

Having described the three harmful mutations in NAGPA, Kornfeld's group is now performing biochemical analyses on the other two mutated genes Drayna's group identified: GNPTAB and GNPTG. Drayna and his colleagues estimate that these three mutated genes account for only about 10 percent of people who stutter with a family history. As such, they are continuing the search for additional genes responsible for stuttering.

This work was supported by grants from the National Institutes of Health (NIH) and from the National Institute on Deafness and Other Communication Disorders, which is a part of the NIH.

Recommend this story on Facebook, Twitter,
and Google +1:

Other bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by Washington University School of Medicine. The original article was written by Julia Evangelou Strait.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal References:

  1. W.-S. Lee, C. Kang, D. Drayna, S. Kornfeld. Analysis of Mannose 6-Phosphate Uncovering Enzyme Mutations Associated with Persistent Stuttering. Journal of Biological Chemistry, 2011; 286 (46): 39786 DOI: 10.1074/jbc.M111.295899
  2. Changsoo Kang, Sheikh Riazuddin, Jennifer Mundorff, Donna Krasnewich, Penelope Friedman, James C. Mullikin, Dennis Drayna. Mutations in the Lysosomal Enzyme?Targeting Pathway and Persistent Stuttering. New England Journal of Medicine, 2010; 362 (8): 677 DOI: 10.1056/NEJMoa0902630

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/D_4v9s2rBmM/111122162834.htm

james arthur ray james arthur ray elisabeth shue erin brockovich avastin avastin robert wagner

Wednesday, November 23, 2011

The Muppets take ?Saturday Night Live?

NBC

The Muppets joined host Jason Segel on "Saturday Night Live."

By Ree Hines

It seems the Muppets are everywhere lately, as the felt friends have been making the TV rounds to promote their upcoming, self-titled movie. Over the weekend, Kermit and the gang stormed yet another show ? ?Saturday Night Live.?

Jason Segel, one of the flesh and blood stars of ?The Muppets,? served as the evening?s host. At least he tried to. It seemed the Muppets were under the impression they were all hosting the show, and they weren?t happy to learn otherwise.

?No, no, no, it makes perfect sense that they?d pick Jason, Piggy,? Kermit said with plenty of sarcasm. ?I mean, when people go to a Muppet movie, they say, ?Gee, I can?t wait to see the human!?

Segal tried to defend the casting decision.

?There?s a perfectly good reason why I?m hosting and not you,? he explained. ?Namely, well for one, half you guys aren?t even wearing pants.?

?Hey, that?s below the belt!? Rowlf the Dog shot back.

Despite the fact that Kermit wasn?t really a host, he did manage to make one more appearance during the show when he joined Seth Meyers for the latest edition of ?Really!?!?

What were your favorite "SNL" skits of the night? Tell us on our Facebook page.

?

Related content:

Source: http://theclicker.today.msnbc.msn.com/_news/2011/11/21/8931429-the-muppets-take-saturday-night-live

exotic animals scott hall lra lra collegeboard kelsey grammer coco rocha

PSA: Sharing iPhone 4S contacts also shares Siri relationships

Just a heads up — if you send a contact via your iPhone 4S‘ built in sharing feature, you also share everything in that contact, including relationships set up by Siri. For many this may not be a big deal, but if you value your privacy or...


Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/ufNUZrXmwB8/story01.htm

jacqueline laurita mcfadden mcfadden ponder ponder loretta lynn extract

Paleontologist describes large nest of juvenile dinosaurs, first of their genus ever found

Paleontologist describes large nest of juvenile dinosaurs, first of their genus ever found [ Back to EurekAlert! ] Public release date: 21-Nov-2011
[ | E-mail | Share Share ]

Contact: Todd McLeish
tmcleish@uri.edu
401-874-7892
University of Rhode Island

Discovery sheds light on early development, parental care

KINGSTON, R.I. November 21, 2011 A nest containing the fossilized remains of 15 juvenile Protoceratops andrewsi dinosaurs from Mongolia has been described by a University of Rhode Island paleontologist, revealing new information about postnatal development and parental care. It is the first nest of this genus ever found and the first indication that Protoceratops juveniles remained in the nest for an extended period.

The findings were reported in the most recent issue of the Journal of Paleontology.

David Fastovsky, URI professor of geosciences, said the bowl-shaped nest measuring 2.3 feet in diameter was found in the Djadochta Formation at Tugrikinshire, Mongolia.

"Finding juveniles at a nest is a relatively uncommon occurrence, and I cannot think of another dinosaur specimen that preserves 15 juveniles at its nest in this way," he said.

The analysis of the 70-million-year-old nest by Fastovsky and his colleagues found that all 15 dinosaurs at least 10 of which are complete specimens were about the same size and had achieved the same state of growth and development, suggesting they represent a single clutch from a single mother. The discovery also indicates that the young dinosaurs remained in the nest through the early stages of postnatal development and were cared for by their parents.

Protoceratops grew to about 6 feet long and may have taken as long as 10 years to reach full size. Those Fastovsky found in the nest were likely less than one year old when they died.

"I suspect that the preserved animals were rapidly buried by the shifting, accumulating sands that must have constituted the bulk of sedimentation in this setting," he said. "Death likely occurred during a desert sandstorm. My guess is that the initial and present-day dryness contributed significantly to the superb preservation, not just of Protoceratops, but of all the fossils from this unit."

Fastovsky calls Protoceratops "a fascinating and unexpected mass of contradictions." It is an herbivore that lived in a sand sea much like the Sahara Desert and likely bestowed significant parental care on a relatively large number of offspring, perhaps because it lived where mortality was quite high.

A wide variety of theropod dinosaurs lived in Mongolia at the time, some of which, including the notorious Velociraptor, probably ate young Protoceratops'.

"Juvenile Protoceratops mortality may have been rather high, not only from predation but from a potentially stressful environment, and large clutches may have been a way of ensuring survival of the animals in that setting," he said. "Nonetheless, if preservation is any indicator of abundance in life, then during the time represented by the Djadochta Formation, Protoceratops were a very common feature of Mongolian Late Cretaceous desert landscapes."

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Paleontologist describes large nest of juvenile dinosaurs, first of their genus ever found [ Back to EurekAlert! ] Public release date: 21-Nov-2011
[ | E-mail | Share Share ]

Contact: Todd McLeish
tmcleish@uri.edu
401-874-7892
University of Rhode Island

Discovery sheds light on early development, parental care

KINGSTON, R.I. November 21, 2011 A nest containing the fossilized remains of 15 juvenile Protoceratops andrewsi dinosaurs from Mongolia has been described by a University of Rhode Island paleontologist, revealing new information about postnatal development and parental care. It is the first nest of this genus ever found and the first indication that Protoceratops juveniles remained in the nest for an extended period.

The findings were reported in the most recent issue of the Journal of Paleontology.

David Fastovsky, URI professor of geosciences, said the bowl-shaped nest measuring 2.3 feet in diameter was found in the Djadochta Formation at Tugrikinshire, Mongolia.

"Finding juveniles at a nest is a relatively uncommon occurrence, and I cannot think of another dinosaur specimen that preserves 15 juveniles at its nest in this way," he said.

The analysis of the 70-million-year-old nest by Fastovsky and his colleagues found that all 15 dinosaurs at least 10 of which are complete specimens were about the same size and had achieved the same state of growth and development, suggesting they represent a single clutch from a single mother. The discovery also indicates that the young dinosaurs remained in the nest through the early stages of postnatal development and were cared for by their parents.

Protoceratops grew to about 6 feet long and may have taken as long as 10 years to reach full size. Those Fastovsky found in the nest were likely less than one year old when they died.

"I suspect that the preserved animals were rapidly buried by the shifting, accumulating sands that must have constituted the bulk of sedimentation in this setting," he said. "Death likely occurred during a desert sandstorm. My guess is that the initial and present-day dryness contributed significantly to the superb preservation, not just of Protoceratops, but of all the fossils from this unit."

Fastovsky calls Protoceratops "a fascinating and unexpected mass of contradictions." It is an herbivore that lived in a sand sea much like the Sahara Desert and likely bestowed significant parental care on a relatively large number of offspring, perhaps because it lived where mortality was quite high.

A wide variety of theropod dinosaurs lived in Mongolia at the time, some of which, including the notorious Velociraptor, probably ate young Protoceratops'.

"Juvenile Protoceratops mortality may have been rather high, not only from predation but from a potentially stressful environment, and large clutches may have been a way of ensuring survival of the animals in that setting," he said. "Nonetheless, if preservation is any indicator of abundance in life, then during the time represented by the Djadochta Formation, Protoceratops were a very common feature of Mongolian Late Cretaceous desert landscapes."

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2011-11/uori-pdl112111.php

occupy wall st occupy wall st the graduate holly madison tragedy of the commons tragedy of the commons casey jones